However, paradoxical secretion of alternative anterior pituitary (AP) hormones has been reported in multiple instances of pituitary adenoma, including GHoma patients responding to thyrotropin-releasing hormone (TRH) with GH secretion (6–9) and acromegaly patients producing prolactin (PRL) upon GHRH administration (10). The gene discussed is TRH; the disease is pituitary gland adenoma.