In a similar vein, while intratumoral implantation of IL-12 transfected DCs showed some anti-tumor effects, addition of systemic 4-1BB agonist antibodies led to complete cures in some cases of both directly injected and untreated contralateral MC38 colon adenocarcinomas (150). The gene discussed is TNFRSF9; the disease is colon adenocarcinoma.