IGFBP2 and breast cancer: However, one of these studies did find evidence of a significant modification of the association of IGFBP-2 with risk of breast cancer by BMI, with those at or above 26 kg/m2 showing evidence of decreased risk of breast cancer with increasing IGFBP-2, an association not seen in women under 26 kg/m2 [33], whereas another suggested that there was a reduction in risk with increased IGFBP-2 when restricted to ER-positive breast cancer only [30].