The platelets store numerous fibrogenic mediators and contribute to chronic tissue fibrosis in SSc by release into tissue of TGF-β1, TGF-β2, PDGF-A, B, C, D, LPA, S1P, adenosine, bFGF, CTGF, and IGF-1. The gene discussed is TGFB1; the disease is systemic sclerosis.