To what extent BMP-7, TNFα, IL-10, IFNγ, or other antifibrotic mediators or mechanisms try to counter the drivers of fibrosis such as TGF-β, IL-4/IL-13, IL-6/IL-6R-Gremlin-1 in SSc is unknown but provides candidates to be the focus of future studies. This evidence concerns the gene IL4 and systemic sclerosis.