CNR2 and Bloom syndrome: Additionally, blocking CB1 receptor in BLM-treated mice with FAAH blocked by JNJ1661010 prevented the enhanced fibrosis induced by BLM treatment, whereas blocking CB2 further enhanced skin fibrosis in BLM-treated mice with FAAH blocked by JNJ1661010, suggesting CB1 mediated fibrosis whereas CB2 dampened fibrosis as a result of increased EC present because of blocking FAAH (432).