MMP1 and systemic sclerosis: Levels of other miRNAs have been found to differ in patients with SSc compared to healthy controls as follows: serum miR-142-3p was higher in SSc patients than healthy controls (106); levels of miR-21 were increased, whereas levels of miR-145 and miR-29b were decreased in SSc lesional fibroblasts (94); miR-92a is more elevated in sera and SSc lesional fibroblasts than in normal healthy controls and may downregulate MMP-1 (107); and levels of miRNA-7 were found to be reduced in sera and lesional fibroblasts from patients with localized scleroderma and may regulate CI expression (102).