DNAX accessory molecule-1 (DNAM-1) modulates adhesion; co-stimulates T lymphocytes; expresses on most CD4+ and CD8+ T cells, NK cells, monocytes, platelets, and some B cells; and is found to be expressed on inflammatory cells in biopsies of lesional skin of patients with SSc (191). The gene discussed is CD8A; the disease is systemic sclerosis.