NG-2 cells have been documented as GFAP(+) in a variety of forms of injury and disease models including in the area surrounding demyelination in multiple sclerosis (Nair et al., 2008) while viral demyelination evokes proliferation of O4(+)/GFAP(+) cells in the spinal cord (Godfraind et al., 1989), and anti-galactocerebroside (GC) induced demyelination resulted in proliferation of GFAP(+) GC(+) cells (Carroll et al., 1987). This evidence concerns the gene IGKV1D-37 and Peripheral demyelination.