Our recent studies have demonstrated that exposure to toxic metal manganese (Mn), which causes Parkinsonian disorders in humans (Crossgrove and Zheng, 2004; Racette et al., 2012), results in an elevated neurogenesis activity in the SVZ and RMS; the phenomenon appears to be associated with an increased expression of divalent metal transporter-1 (DMT1) in the SVZ (Fu et al., 2015). This evidence concerns the gene SLC11A2 and parkinsonian disorder.