Studies conducted in iNOS-deficient mice and/or under iNOS inhibition have provided evidence that inducible NO governs a broad spectrum of processes, such as recruitment and adhesion of leukocyte [7, 8], inflammatory diseases [9, 10], wound healing [11, 12], ischemia [13–15], and tumor-induced angiogenesis [16]. This evidence concerns the gene NOS2 and ischemia.