Comparing with 4,300 European American individuals from the NHLBI GO Exome Sequencing Project (ESP), there was a trend for a higher burden of rare missense variants in relative to controls the CDKN2A gene (p16INK4A and p14ARF) in children with ALL (0.71% versus 0.23%, P=0.0045, Fisher's exact test, Fig. 3). Here, CDKN2A is linked to acute lymphoblastic leukemia.