This early disease onset suggests a strong inherited genetic basis for ALL susceptibility, and recent genome-wide association studies (GWAS) have discovered at least six risk loci: ARID5B, IKZF1, CEBPE, PIP4K2A-BMI1, GATA3 and CDKN2A–CDKN2B5, 6, 7, 8, 9, 10. The gene discussed is ARID5B; the disease is acute lymphoblastic leukemia.