Immunohistochemical analyses confirmed these findings and further showed that low grade B-cell lymphomas express VCP at a level comparable to lymphocytes present in the mantle zone of lymphoid follicles, whereas VCP expression in medium and high grade B-cell lymphomas was more comparable to that found in lymphocytes of germinal centers (Fig. 1b). Here, VCP is linked to B-cell non-Hodgkin lymphoma.