YY1 is a ubiquitously expressed transcription factor, and the YY1-miRNA axis, as NF-kB- YY1-miR-29 signaling axis in rhabdomyosarcoma [32, 33] and YY1-miR-1-Pax 7 axis in skeletal myogenesis [34], has been identified in different cellular processes. This evidence concerns the gene NFKB1 and rhabdomyosarcoma.