The most common non-hematological adverse events related to MK-2206 included rash (20/24; 83.3 %), an elevated insulin c-peptide level (16/24; 66.7 %), stomatitis (14/24; 58.3 %), pyrexia (13/24; 54.2 %), hyperglycemia (12/24; 50.0 %), diarrhea (10/24; 41.7 %), and an elevated blood creatinine level (8/24; 33.3 %). The gene discussed is INS; the disease is stomatitis.