Further analysis of MLH1 promoter methylation status in the tumor of 4 patients showing MSI-H phenotype and MLH1 protein expression loss with absence of MLH1 deleterious somatic mutation by Multiplex Ligation-dependent Probe Amplification (MLPA) or sequencing, did not detect aberrant methylation discarding the hypothesis of sporadic cancers due to epigenetic inactivation of MLH1 gene [25]. The gene discussed is MLH1; the disease is cancer.