Univariate analysis demonstrated significant association between loss of MMR proteins with the presence of Individual or family history of cancer belonging to HNPCC spectrum (p = 0.001), Lymph node metastasis (p = 0.02), synchronous colorectal cancer (p = 0.0003) and proximal localization (p = 0.00001). Here, MRC1 is linked to hereditary nonpolyposis colon cancer.