In addition, people with low folate intake/high alcohol intake show a higher frequency of promoter methylation of genes involved in CRC carcinogenesis (e.g., APC-1A, p14ARF, p16INK4a, hMLH1, O6-MGMT, and RASSF1A) compared with people with high folate intake/low alcohol intake [47]. The gene discussed is CDKN2A; the disease is colorectal carcinoma.