Nevertheless, one recent report of designed kinase inhibitors using octahedral metal chelate complexes with a ruthenium(II) or iridium(III) metal center demonstrated a highly selective octasporine protein kinase inhibitor termed OS4 with a DAPK1-IC50 of 2nM.105 Such a compound deserves further investigation and shows a promising way forward in combating AKI-induced tissue injury. The gene discussed is DAPK1; the disease is acute kidney injury.