Our observations that decrease CXCL1 secretion by SW620 cells inhibited their anchorage-independent and xenograft tumor growth are supported by similar findings in KRAS mutant LS174T CRC cells, whose malignant growth were inhibited by CXCL1 siRNA or neutralizing α-CXCL1 antibody [24, 25]. Here, KRAS is linked to colorectal carcinoma.