Hyperhomocysteinemia is strongly incriminated in the liberation of von Willebrand factor, in activation of V and VIII factors of coagulation, in inhibition of C and S proteins, in lipid peroxidation... These effects combine, and accelerate of the atherosclerotic plaque formation and contributing to subsequent thrombotic and ischemic complications [2, 9]. The gene discussed is VWF; the disease is hyperhomocysteinemia.