APOB and obesity due to melanocortin 4 receptor deficiency: Among diabetes, hypertension, obesity and smoking, a family lipoprotein disorder such as a high level of serum apolipoprotein B (Apo B) or/and a lower level of serum apolipoprotein A-1 accounted for almost all the population attributable risk of ACS, according to the Framingham study [1, 2].