The C57BL and kk-Ay mice were also evaluated at 12 weeks old to study the progression of GBM thickening, showing as C57BL (0.07 ± 0.07) and kk-Ay mice (0.96 ± 0.32), depicting the influence of apelin on GBM thickening. The gene discussed is APLN; the disease is glioblastoma.