We found that CXCL8 and CCL20 did not inhibit osteoblast proliferation nor gene expression of the main matrix proteins COL1, OPN, and OCN. CXCL8 and CCL20 enhanced osteoblast-mediated osteoclastogenesis, partly via IL-6 production, suggesting that CXCL8 and CCL20 may contribute to generalized osteoporosis in RA by affecting bone cell communication. The gene discussed is SPP1; the disease is rheumatoid arthritis.