Interestingly, shRNA-mediated knockdown of Phf6 in a murine B-cell acute lymphoblastic leukemia (B-ALL) model was observed to significantly reduce the rates of tumour proliferation, in contrast to both T-ALL and AML models, where the loss of Phf6 correlates with enhanced tumour progression [24,58]. Here, PHF6 is linked to acute myeloid leukemia.