BBS2 and Bardet-Biedl syndrome: This possibility is supported by several evidences including the synergistic effects of suppressing bbs genes in zebrafish [35], and the variability of the phenotypes of BBS mice [36] and patients carrying mutations in BBS proteins that belong either to the same complex (e.g. chaperonin complex) or related complexes (e.g. chaperonin complex vs BBSome) [37].