As a key determinant of estrogen receptor function and endocrine response[22], FOXA1 participated with ERα and GATA3 in a complex transcriptional regulatory program to drive tumor growth[23] in estrogen receptor-α (ERα)-positive breast tumors, so the absence of estrogen receptor may lead to the decrease of FOXA1 expression. The gene discussed is FOXA1; the disease is neoplasm.