The incidence of HER2 mutations has been reported previously to range from 1% to 6% in NSCLC, and the vast majority of HER2 mutations were represented by a 12 bp duplication/insertion of the amino acid sequence YVMA in exon 20 at codon 776 [7,11,13,25,26]. Here, ERBB2 is linked to non-small cell lung carcinoma.