The putative role of endoplasmic reticulum stress in mediating steatosis and hepatic insulin resistance is supported by the observations that ER-stress is increased in the liver of obese subjects with NAFLD [56], and decreases with weight loss, concomitant to an improvement in hepatic insulin sensitivity and the resolution of steatosis [57]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.