Hence the molar ratio of VLDL-triglyceride secretion rate to VLDL-apolipoprotein B-100 secretion rate, which is an index of the triglyceride content (and therefore, of the size) of newly-secreted VLDL particles from the liver, is more than two-fold greater in people with NAFLD [60]. This evidence concerns the gene APOB and metabolic dysfunction-associated steatotic liver disease.