INS and obesity due to melanocortin 4 receptor deficiency: The basal rate of fatty acid release in the systemic circulation increases directly with increasing body fat mass in both men and women [82], however, independent of the degree of obesity, the presence of NAFLD is typically associated with 35%–45% greater basal lipolytic rates [30,60,83,84] and with impaired insulin-mediated suppression of adipose tissue lipolysis [12,30,83].