Many studies have found that hepatic insulin resistance, i.e., the diminished ability of circulating insulin to suppress hepatic glucose production, is directly related to IHTG content [12,28,29,30,31], independent of age, sex, BMI, waist circumference, percent body fat, and visceral fat mass [12,28,30,31,32,33]. The gene discussed is INS; the disease is Insulin resistance.