The secretion rate of VLDL-apolipoprotein B-100 from the liver, which directly reflects the secretion of VLDL particles themselves (since each VLDL particle contains one molecule of apolipoprotein B-100), is either not different [60] or only slightly greater [145] in subjects with NAFLD than those without NAFLD. The gene discussed is APOB; the disease is metabolic dysfunction-associated steatotic liver disease.