EBV+ DLBCL-e is a molecularly distinct entity characterized by enhanced activity of the NF-κB, signal transducer and activator of transcription 3 (STAT3), MEK/ERK and phosphoinositide 3-kinase (PI3K)/Akt pathways, mostly induced by EBV products [6]. This evidence concerns the gene NFKB1 and diffuse large B-cell lymphoma.