CD2AP is an adaptor molecule involved in dynamic actin remodeling and membrane trafficking, and CLU encodes clusterin, which is a molecular chaperone,39 is present in senile plaques, and has been shown to modulate Aβ oligomer assembly.40 We previously reported rare SNPs and small structural variants within the CLU gene that were associated with LOAD.41 Here, CLU is linked to Senile plaques.