The first large‐scale genome‐wide association studies (GWAS) using common single nucleotide polymorphisms (SNPs) identified CLU, PICALM, CR1, and BIN1 as late onset Alzheimer disease (LOAD) susceptibility loci,1, 2, 3 which were widely confirmed by others.4, 5 The effect sizes of these genetic associations were much smaller than for APOE,2, 6 with odds ratios ranging from 1.16 to 1.20. Here, BIN1 is linked to Alzheimer disease.