Thus, the inhibition of CA2 by M01 reduces the chances of Alzheimer's disease after cerebrovascular disease; (2) studies suggest that MIF is upregulated in the brain after cerebral ischemia, and disruption of the Mif gene in mice leads to a smaller infarct volume and better sensory-motor function after transient middle cerebral artery occlusion [45]. This evidence concerns the gene CA2 and Alzheimer disease.