Including 150 patients with mild-to-moderate diabetic nephropathy, A. P. Silva et al. in their paper entitled “Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients” found that reduced magnesium and high levels of fibroblast growth factor-23 were independent predictors of mitral valve calcification and of increased carotid intima media thickness. This evidence concerns the gene FGF23 and diabetic kidney disease.