CD40LG and infection: In our evaluation, the sensitivity of Typhidot was extremely low (26.7%) and so was the specificity (61.5%) compared to 67% and 54% in a previous study in Bangladesh.4 The PPV was 7.4% and NPV was 87.9% compared to 85% positive and 81% NPVs according to a research in Bangladesh.11 Even though Typhidot detects IgM during the acute phase and IgG later, it displayed very low positives in the blood culture positive individuals (4 out of 15)and many positives (50 out of 80) in other bacteremic infections and diseases.