It has a rivalry effect for release of glucocorticoid, adrenocortical hormone, sympathetic neurotransmitter and constrictive vasoactive peptide, as well as the positive function of natriuretic and vasorelaxing, so the BNP can effectively prevent water-sodium retention and improve heart function.18 It has reported that BNP levels increased significantly in patients with heart failure.19 There are few reports about the effect of perioperative BNP on heart function of patients undergoing on-pump CABG surgery on a beating heart. This evidence concerns the gene NPPB and heart failure.