The VEGF in low oxygen conditions are reported to prolong the survival of malignant cell, and thus this gene has a critical role in tumor growth and invasion as well as development of malignant tumor.11 Only two studies have assessed the role of common VEGF polymorphisms in the risk of osteosarcoma in a Chinese population.16,17 Therefore, the aim of this present study was to assess the association between the six common SNPs and the risk of osteosarcoma, and their association with environmental factors. This evidence concerns the gene VEGFA and osteosarcoma.