It is reported that many environmental and genetic factors can influence the individuals susceptibility to the carcinogenesis of osteosarcoma.9,18 Increasing evidences have reported that genetic polymorphisms play an important role in development of osteosarcoma, especially for angiogenesis genes.4-6 It is well known that angiogenesis plays an important role in the process of tumor growth, and can affect the tumor invasion and metastasis.19,20 The VEGF is highly polymorphic, and its polymorphisms are reported to influence the expression of VEGF.15 This evidence concerns the gene VEGFA and osteosarcoma.