XRCC1 and Familial prostate cancer: These coding polymorphisms were detected at codons 194 (Arg>Trp), 280 (Arg>His) and 399 (Arg>Gln) in different cancers including prostate cancer, but the results are inconsistent.10-13 These non- conservative amino acid changes may alter XRCC1 function and may have an impact on individual susceptibility to prostate cancer.