VEGFA and neoplasm: Particularly, the regulation of VEGF gene expression is associated with many factors such as differentiation, hormones, cytokines and partial pressure of oxygen.7 As the most potent vascular endothelial cell division-promoting agent, VEGF is key for the onset, invasion and metastasis of tumors, which prevents tumor cells from immune response by facilitating tumor growth and by hindering maturation of host-specific antigen-presenting cells.8