GA+AA genotype of ERCC2 rs1799793 and GC+CC genotype of NBN rs1805794 were associated with increased risk of osteosarcoma, but that gene polymorphisms of ERCC1 rs11615 and rs3212986, ERCC2 rs13181, NBN rs709816, RAD51 rs1801320, rs1801321 and rs12593359, and XRCC3 rs861539 were not correlated with risk of this cancer. This evidence concerns the gene XRCC3 and osteosarcoma.