We found that GA+AA genotype of ERCC2 rs1799793 or GC+CC genotype of NBN rs1805794 were associated with an increased risk of osteosarcoma in females, and the ORs(95%CI) were 2.42(1.20-4.87) and 2.01(1.07-4.23), respectively. The gene discussed is ERCC2; the disease is osteosarcoma.