For NBN rs1805794, previous studies have showed that NBN SNPs can influence the DNA repair capacity, and NBN rs1805794 genotypes confer to differences in levels of DNA damage and osteosarcoma risk.3,4 Our study is in agreement with previous studies, GC+CC genotype of NBN rs1805794 was associated with increased risk of developing osteosarcoma. This evidence concerns the gene NBN and osteosarcoma.