Furthermore, with the Cancer Genome Atlas (TCGA) database (http://cancergenome.nih.gov/) , we found that C21orf2 and LRRC3 had lower expression levels in hepatic carcinoma (P = 0.049 and 2.29 × 10−7, respectively), and TRPM2 had higher expression levels in hepatic carcinoma (P = 0.041), suggesting the importance of these genes in the development of hepatic disease. This evidence concerns the gene LRRC3 and liver disorder.