PRTN3 and brain cancer: One remarkable discovery is that components of the synMuv B chromatin remodeling complex, which include homologs of the tumor suppressors Retinoblastoma (Rb or LIN-35) and Malignant Brain Tumor (MBT or LIN-61), actively repress the somatic expression of germline-specific ribonucleoprotein aggregates called germ granules (Unhavaithaya et al. 2002; Wang et al. 2005; Cui et al. 2006; Petrella et al. 2011; Wu et al. 2012) .