ESR1 and obesity due to melanocortin 4 receptor deficiency: Subsequently, we investigate whether individual genes in this obesity-associated tGSS derived from BC tumors are significantly enriched among the 70 BC rGSSs which were previously reported to be associated with clinical observations such as response to chemotherapy, distant metastasis, ER-alpha status, tumor subtypes and grades, as well as clinical outcomes such as patient prognosis.