IGF1 and obesity due to melanocortin 4 receptor deficiency: When we compared the EFDs for both the obesity-associated tGSS and IGF1 pathway tGSS, results suggested that there is a stronger association of the IGF1 pathway tGSS's genes with the 70 BC rGSSs than observed for the obesity-associated tGSS's genes with the 70 BC rGSSs (Figure 4D).