We also corroborated that, as expected, HIV infection resulted in higher levels of CD8+ T-cell activation since early times p.i [15.2% (7.1–30.6) in baseline PHI samples] compared to both ECs [8.2% (3.2–12.8); p = 0.0460] and normal values found in HDs [0.38% (0.18–2.19); p = 0.0007; Fig. 2D]. The gene discussed is CD8A; the disease is HIV infectious disease.