We finally challenged a panel of MM cell lines (LP-1, MM.1R, RPMI 8226) and MCL cell lines (Granta-519 and Jeko-1), which differed in their degree of BTK expression and ibrutinib sensitivity, with sub-effective concentrations of BTZ, CFZ, or LU-102, in the presence or absence of ibrutinib (Fig. 5), and calculated the respective combination indices for synergy (CI) after assessment of cytotoxicity by MTT assay. The gene discussed is BTK; the disease is Miyoshi myopathy.