In the other hand, PCR analysis of BM samples also showed reduction in VEGF, HIF-1α and ANGPT-2 gene expression in HF-treated mice (Fig. 6c), whereas ANGPT-1, HGF, TIMP2 and CXCL10 had no change in leukemic mice (data not shown). The gene discussed is CXCL10; the disease is hydrops fetalis.