VEGF, HER-2, and EGFR mRNA expression levels in the lymph node metastasis group were 1.05 ± 0.10, 1.02 ± 0.08, and 0.97 ± 0.04, while the expression levels of the three genes without lymph node metastasis were 1.00 ± 0.07, 0.97 ± 0.08, and 0.93 ± 0.06 The expression levels with lymph node metastasis were higher than those without lymph node metastasis (P < 0.05). The gene discussed is EGFR; the disease is metastatic malignant neoplasm in the lymph nodes.