According to the mutation frequency, some driver mutations occurred in some of critical genes, including MUC16 (1720 mutations), TP53 (1113 mutations), PTEN (1113 mutations), PIK3CA (291 mutations), NF1 (288 mutations), VCAN (274 mutations), ATM (236 mutations) and LAMA1 (230 mutations) in all the pan-cancer samples. The gene discussed is TP53; the disease is cancer.