The assumptions were that genes controlled by SPIB are differentially expressed (i.e. P-value of KSTest < = 0.05) in ABC DLBCL cells treated as the above-mentioned two conditions, and that SPIB regulated genes are those genes with either a type I or a type II SPIB binding sites located between 5 kb upstream and 1 kb downstream to the transcription start site. The gene discussed is SPIB; the disease is diffuse large B-cell lymphoma.