Moreover, recent data from syngeneic murine tumour models of Lewis lung carcinoma (LLC) and B16-F1 (B16) melanoma cancer cell lines showed that lactate-induced stabilisation of HIF-1α increased arginase 1 expression and consequently M2-like polarisation of tumour-associated macrophages [83] (Fig. 2). The gene discussed is HIF1A; the disease is neoplasm.