SOD1 and amyotrophic lateral sclerosis: Interestingly, the structural features of the non-native oligomers identified here are in keeping with expectations based on studies of soluble and insoluble SOD1 species in protein inclusions isolated from human patients (Rakhit et al., 2007; Bosco et al., 2010; Forsberg et al., 2010) and mouse models of ALS (Rakhit et al., 2007; Bosco et al., 2010; Zetterström et al., 2013).