For example, SEDI antibodies raised against native–dimer interface residues 143–151, and for which there is no cross-reactivity with monomeric SOD1, could identify misfolded SOD1 in degenerating neurons of presymptomatic mice models of ALS, and also in mice overexpressing wild-type SOD1 (Rakhit et al., 2007). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.