While affection spans across both DMN and SN, the relationship to deviant food intake seemed to be quite different: dACC may be seen as a basic biological marker of aberrant insulin related metabolic state in obesity, abnormal resting state in precuneus could be related more directly with increased subjective motivation towards increased eating behavior especially in the situation of hunger. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.