ABCB1 and non-small cell lung carcinoma: In summary, this study demonstrates, for the first time, the anticancer potential of 21α-MMD with a redox regulatory mechanism and also outlines the mechanistic action of 21α-MMD in inhibiting the growth, survival and metastasis of human NSCLC cells and influence a mechanism that results in the influence on suppression of P-gp/MDR1-associated MDR in drug-resistant human NSCLC cells.