To evaluate and screen CIMP status of cancers, Park etal [27] proposed a panel of genes consisting of p16/CDKN2A, MINT1, MINT2, MINT31 and MLH1 (referred as classical CIMP panel).The frequencies of hypermethylation in a panel of six genes (ECAD, p16, DAPK, MGMT, RASSF1 and TIMP3) were found very high in head and neck cancer [28]. This evidence concerns the gene MLH1 and cancer.