Therefore, we proposed a CIMP panel of seven genes, including; DAPK (death-associated protein kinase), RASSF1 (Ras association domain family-1), BRCA1 (breast cancer 1), MLH1 (mutL homology 1), p16 (cyclin-dependent kinase inhibitor 2A), ECAD (epithelial cadherin), GSTP1 (glutathione S-transferase pi-1), and three methylated loci such as MINT1, MINT2 and MINT31 (methylated in tumor 1, 2 and 31 respectively). This evidence concerns the gene MLH1 and neoplasm.