MLH1 and neoplasm: Tumor tissues had much higher genes/loci hypermethylation frequency compared to normal tissue samples (32.4% vs. 13.3% for p16, 29.6% vs. 11.1% for DAPK, 18.3% vs. 8.9% for BARC1, 31% vs. 15.6% for GSTP1, 32.4% vs. 8.9% for ECAD, 50.7% vs. 22.2% for RASSF1, 5.6% vs. 2.2% for MLH1, 43.7% vs. 13.3% for MINT1, 52.1% vs. 11.1% for MINT2 and 46.5% vs. 17.8% for MINT31).