Our present investigation had covered a broad group of tumor-related pathway genes, including p16 (cell-cycle control), DAPK, RASSF1 (apoptosis), BRCA1, MLH1 (DNA repair), ECAD (cell-cell adhesion), GSTP1 (carcinogen metabolism), MINT1, MINT2 and MINT31 (methylated loci in tumors). This evidence concerns the gene MLH1 and neoplasm.