But even more prominent effect on Pyk2 phosphorylation was found out in all investigated cell lines after treatment with AMCM, with the strongest effect in glioma cells with the low basic level of Pyk2 phosphorylation: U87 and HS683 (70% and 150% up regulation correspondingly), compare to glioma cells with high basic level of Pyk2 phosphorylation: A172 and C6 (40% up regulation). The gene discussed is PTK2B; the disease is central nervous system cancer.