IGFBP3 and central nervous system cancer: These might suggest that in addition to Pyk2 other pathways may be involved in the regulation of basal rates of migration in gliomas such as Insulin-like growth factor binding protein 3 (IGFBP-3) that has been implicated in the pathogenesis of gliomas and was shown to be involved in proliferation and the invasive capacity of glioma cells [53].