Other studies demonstrated that Culllin1 (Cul1) is increased significantly in malignant brain tumors, and that silencing of Cul1 in glioma cells inhibited the cell migration and invasion abilities as well as down-regulated MMP-2 and MMP-9 expression that also greatly contribute to the reduced cell invasion and migration abilities [54]. The gene discussed is CUL1; the disease is central nervous system cancer.