These results allude to a HO-1-SIRT1 axis where the antioxidant properties of HO-1 preserve the functional integrity of SIRT1, which, in turn, works with HO-1 to attenuate the development of steatohepatitis and progression to hepatic fibrosis while restoring metabolic balance. The gene discussed is SIRT1; the disease is Hepatic fibrosis.