Data reported here showed that the administration of Citrus nanovesicles strongly suppressed tumor growth and we confirmed, in vivo, that this effect was due not only to TRAIL-mediated apoptosis but also to the inhibition of angiogenic processes, as shown by the reduced levels of pro-angiogenic cytokines VEGF-A, IL6 and IL8. Here, CXCL8 is linked to neoplasm.