To further investigate other mechanisms that might be involved in nanovesicle-dependent tumor inhibition, we performed a multiplex cytokine analysis and we found that the administration of nanovesicles led to the decrease of the pro-angiogenic factors, such as VEGF-A, IL6 and IL8 in the serum of treated-mice compared with untreated ones (Figure 5D, upper panel). The gene discussed is IL6; the disease is neoplasm.