Among the SLE patients, the positive rate of anti-RRP8 antibody was significantly higher in LN than that in SLE without nephritis (63.6% (n = 7) vs 12.5% (n = 8), respectively; p = 0.00017, odds ratio 12.25, 95% confidence interval 2.9–51.4). The gene discussed is RRP8; the disease is systemic lupus erythematosus.