Antibodies against RRP8, TNP1, sperm protamine P1 (PRM1), and protamine 2 (PRM2), were detected in the sera from SLE patients, while antibody against junctional sarcoplasmic reticulum protein 1 (JSRP1) was detected not only in the sera from SLE patients but also in sera from DM and SSc patients. The gene discussed is PRM2; the disease is systemic lupus erythematosus.